Jacob's Ladder, after its rework, is now extremely effective in clearing out groups of enemies even if they're not hit directly.
"Room clearer" items such as Toxic Shock and "Boss killer" items such as Head of Krampus are also very useful for speeding up progress. Damage and Tear boosting items are thus a potential priority, making Devil Deals desirable because of their DPS heavy item pool. Anything that could help to clear rooms faster is going to alleviate some of the difficulty of this challenge.It is important to be careful and adjust to the speed-up. Isaac's highly increased speed is a powerful asset to rapidly completing this run but can be dangerous as the player may accidentally run over spikes or into enemies/bullets that they otherwise would not run into.Floor skipping with We Need to Go Deeper! and such are also valuable time-savers, as long as the player is confident with their current set of items. The Compass, the Crystal Ball and The Mind are very useful if this is the desired strategy, as is IV - The Emperor card. Find and visit the Treasure Room, occasionally the shop, and the boss, then move on as soon as possible. If the player wishes to beat the timer, it might be a good idea to cut down exploring to a minimum.The adverse effect of not finishing the run in within 16 minutes (periodic damage every 10 seconds) can be avoided simply by beating the timer. Clicker can be used to change Isaac into a more powerful character such as Azazel or The Forgotten, allowing the player to clear rooms more quickly.In the same vein, Plan C is also useful, though only against the final boss. The Bible can be used to instantly kill Mom and It Lives, making it a more valuable item in this run.The invincibility from it can also block timed damage occasionally. Since Isaac starts with increased speed, Taurus can be used to start every room with the My Little Unicorn effect making it effective for clearing rooms quickly.The Ludovico Technique shouldn't be picked up without high shot speed, as it will move slower than most enemies.Stop Watch no longer requires the player to take damage in order to activate the slowing effect.Getting the Stop Watch will make this challenge easier, since it will slow all enemies in the room when Isaac takes damage, counteracting their increased speed.Certain cards and runes, such as V - The Hierophant, VI - The Lovers, VII - The Chariot, XIX - The Sun, Rune of Algiz, and Rune of Dagaz, can also act as health regeneration or protection to counteract the timed damage or the increased difficulty in general. Blank Card is a powerful item in this run, as there are cards and runes such as IV - The Emperor, XIX - The Sun, Rune of Ansuz, and Rune of Ehwaz, all of which can enable faster progression through the game.Items that generates health or protection thus help greatly, These include The Wafer, Cancer, Yum Heart, Unicorn Stump, Prayer Card, and many many more. Not only will health compensate for the damage taken, be it from the more difficult rooms/bosses or the timed damage, but it can also be used for Devil Deals to access its high DPS item pool. Health is always important, but even more so in this challenge.
MY BINDING OF ISAAC REBIRTH GAME CLOSES AFTER 2 SECONDS FULL
Note that the time limit is not a "hard" one and that the game is not over when the countdown timer reaches 0 however, from that point onwards Isaac will start taking half a heart of damage every 10 seconds, or a full heart of damage starting from chapter 4.
More importantly, the 16-minute soft time limit is also very hard to beat and may force the player to forgo exploring for rewards that might have helped them later on. Firstly, the increased speed for both the enemies and Isaac can make most routine rooms and bosses challenging. This is arguably one of the hardest challenges in the game, for two major reasons.
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